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. 2022 Oct 10;23(19):12019. doi: 10.3390/ijms231912019

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The scheme of concept and experimental design for the entire study. (1) Bletilla striata Polysaccharide (BSP) extract from B. Striata was produced by the ethanol precipitation method. (2) BSP, Methylcellulose (MC), and Methylparaben (MP) were blended with the different compositions of developed hydrogels, which were abbreviated as M2Bx, M5Bx, and M8Bx groups, where M and B stand for MC and BSP, respectively, and the numbers refer to M percentage and x refers to BSP percentages: 0.5%, 1%, and 2%. (3) MB hydrogel was a general term to represent all hydrogels. (4) the developed MB hydrogel used to serve as wound dressing was applied to a rat model to evaluate its efficacy towards wound healing. (5) The scheme of MB hydrogel to induce cell migration/proliferation and to improve tissue repair during the wound-healing process.