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. 2022 Sep 24;23(19):11250. doi: 10.3390/ijms231911250

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gemcitabine, mycophenolate mofetil, and mycophenolic acid can inhibit SADS-CoV replication. (A) The expressions of viral proteins in cells after 48 h SADS-CoV infection with different treatments. (B) The growth kinetics of SADS-CoV in the presence of gemcitabine (6.25 μM), mycophenolate mofetil (12.5 μM), and mycophenolic acid (12.5 μM), respectively. (C) The expression of SADS-CoV RNA in the supernatant at 24 hpi, 36 hpi, and 48 hpi in the presence of indicated compounds. DMSO was added as the positive control. The experiments were repeated at least twice. Error bars represent ±1 SD, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by Student’s t-test.