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. 2022 Oct 4;23(19):11793. doi: 10.3390/ijms231911793

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The multi-responsive potential of magnetic polymeric micelles. (A-C) DOX-Fe₃O₄@PAAP micelles produced from P(AAm-co-AN)-g-PEG, SPIONs and DOX, evidenced a pH and NIR irradiation controlled release of DOX: (A) Thermographic images of Fe₃O₄@PAAP micelles after exposure to NIR radiation (808 nm laser at 2 W cm⁻²); (B) Cumulative release curves of DOX in PBS (pH 5.5, 6.5 and 7.4) with or without serum at pH 7.4; (C) Cumulative release curves of DOX in PBS (pH 5.5, 6.5, and 7.4) upon irradiation with a NIR laser for 3 min. (D) Cumulative release curves of DOX from PPI-b-TEGME, SPIONs and DOX micelles at 37 °C, 45 °C, and after a 5 min exposure to an AMF. Adapted with permission from Refs. [8, 32]. Copyright 2022, The Royal Society of Chemistry.