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BTB does not require TDAG8 to inhibit myofibroblast differentiation. Fibroblasts were transfected for 18 h, upon which time media was changed. After 54 h, fibroblasts were challenged with 1 ng/mL TGFβ and/or 50 µM BTB. Fibroblasts were incubated for another 48 h prior to protein harvest. TDAG8 knockdown was confirmed (A) and lysates were examined for expression of αSMA (B). Data were analyzed by ANOVA. n = 3 technical replicates/group. * p < 0.05, ** p < 0.01, **** p < 0.0001.
