Table 2.
MicroRNAs as biomarkers for diagnosis and prognosis of HCC.
| miRNA | Sample | Expression | AUC | Biomarker | Reference |
|---|---|---|---|---|---|
| miR-452-5p | Tissue | ↑ | 0.83 | Diagnosis/Prognosis | [62] |
| miR-4661-5p | Tissue | ↑ | 0.725 | Diagnosis/Prognosis | [62] |
| miR-760 | Tissue/Serum | ↑ | 0.707 | Diagnosis/Prognosis | [66] |
| miR-7-5p | Tissue/Serum | ↑ | 0.641 | Diagnosis/Prognosis | [66] |
| miR-27a | exosomes/Tissue | ↑ | 0.8282 | Diagnosis/Prognosis | [63] |
| miR-18a | exosomes/Tissue | ↑ | 3-miR:0.904 | Diagnosis/Prognosis | [63] |
| miR-20b | exosomes/Tissue | ↑ | 3-miR:0.904 | Diagnosis/Prognosis | [63] |
| miR-221 | exosomes/Tissue | ↑ | 3-miR:0.904 | Diagnosis/Prognosis | [63] |
| miR-184 | Serum | ↑ | 6-miR:0.9535 | Diagnosis | [64] |
| miR-532-5p | Serum | ↑ | 6-miR:0.9535 | Diagnosis | [64] |
| miR-221-3p | Serum | ↑ | 6-miR:0.9535 | Diagnosis | [64] |
| miR-200 | Serum | ↑ | 4-miR:0.92 | Diagnosis | [65] |
| miR-21 | Serum | ↑ | 4-miR:0.92 | Diagnosis | [65] |
| miR-355 | Serum | ↑ | 4-miR:0.92 | Diagnosis | [65] |
| miR-1293 | TEP miRNA | ↑ | 0.78 | Diagnosis | [70] |
| miR-3200-3p | Tissue | ↑ | / | Prognosis | [67] |
| miR-3690 | Tissue | ↑ | / | Prognosis | [67] |
| miR-1269a | Tissue | ↑ | / | Prognosis | [69] |
| miR-421 | Tissue | ↑ | / | Prognosis | [69] |
| miR-326 | Tissue | ↑ | / | Prognosis | [71] |
| miR-21 | Tissue | ↑ | / | Prognosis | [71] |
| miR-212-3p | Tissue | ↑ | / | Prognosis | [72] |
| miR-25 | Tissue | ↑ | / | Prognosis | [73] |
| let-7e | Tissue/Cell | ↑ | / | Prognosis | [74] |
| let-7e | exosomes/Tissue | ↑ | / | Prognosis | [63] |
| miR-652 | exosomes/Tissue | ↑ | / | Prognosis | [63] |
| miR-638 | Cell/exosomes | ↑ | / | Prognosis | [68] |
| miR-5589-3p | Tissue | ↓ | 0.838 | Diagnosis/Prognosis | [62] |
| miR-5589-5p | Tissue | ↓ | 0.879 | Diagnosis/Prognosis | [62] |
| miR-139-3p | Tissue/Serum | ↓ | 0.706 | Diagnosis/Prognosis | [66] |
| miR-5589-5p | Serum | ↓ | 6-miR:0.9535 | Diagnosis | [64] |
| miR-26b-3p | Serum | ↓ | 6-miR:0.9535 | Diagnosis | [64] |
| let-7b-3p | Serum | ↓ | 6-miR:0.9535 | Diagnosis | [64] |
| miR-29a | Serum | ↓ | 4-miR:0.92 | Diagnosis | [65] |
| miR-495-3p | TEP miRNA | ↓ | 0.76 | Diagnosis | [70] |
| miR-125b | exosomes | ↓ | / | Diagnosis | [75] |
| miR-144/451a cluster | Tissue | ↓ | / | Prognosis | [76] |
| miR-140 | Tissue | ↓ | / | Prognosis | [77] |
| mir-150-3p | Tissue/exosomes | ↓ | / | Prognosis | [78] |
TEP: tumor-educated platelet, 3-miR: AUC values of three miRNA combinations appearing in the same paper, 4-miR: AUC values of four miRNA combinations appearing in the same paper, 6-miR: AUC values of six miRNA combinations appearing in the same paper, ↑: Up-regulated expression, ↓: Down-regulation expression.