Table 3.
MicroRNAs as biomarkers for diagnosis and prognosis of GC.
| miRNA | Sample | Expression | AUC | Biomarker | Reference |
|---|---|---|---|---|---|
| miR-455-3p | Tissue | ↑ | 3-miR:0.91 | Diagnosis | [88] |
| miR-135b-5p | Tissue | ↑ | 3-miR:0.91 | Diagnosis | [88] |
| let-7a-3p | Tissue | ↑ | 3-miR:0.91 | Diagnosis | [88] |
| miR-3185 | Tissue/Plasma | ↑ | 4-miR:0.825 | Diagnosis | [83] |
| miR-6083 | Tissue/Plasma | ↑ | 4-miR:0.825 | Diagnosis | [83] |
| miR-6792-3p | Tissue/Plasma | ↑ | 4-miR:0.825 | Diagnosis | [83] |
| miR-659-3p | Tissue/Plasma | ↑ | 4-miR:0.825 | Diagnosis | [83] |
| miR-140 | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-183 | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-30e | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-103a | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-93 | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-142 | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-21 | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-29c | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-424 | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-340 | Serum | ↑ | 12-miR:0.848 | Diagnosis | [84] |
| miR-1290 | Serum | ↑ | 0.6576 | Diagnosis | [89] |
| miR-320a | Serum | ↑ | ≥0.95 | Diagnosis | [90] |
| miR-1260b | Serum | ↑ | ≥0.95 | Diagnosis | [90] |
| miR-6515-5p | Serum | ↑ | ≥0.95 | Diagnosis | [90] |
| miR-130b | Plasma | ↑ | 0.911 | Diagnosis | [79] |
| miR-10a-5p | exosomes | ↑ | 0.801 | Diagnosis | [82] |
| miR-19b-3p | exosomes | ↑ | 0.721 | Diagnosis | [82] |
| miR-215-5p | exosomes | ↑ | 0.78 | Diagnosis | [82] |
| miR-18a-5p | exosomes | ↑ | 0.736 | Diagnosis | [82] |
| miR-145-3p | Tissue | ↑ | / | Prognosis | [85] |
| miR-328-3p | Tissue | ↑ | / | Prognosis | [85] |
| miR-125b-5p | Tissue | ↑ | / | Prognosis | [85] |
| miR-99a-3p | Tissue | ↑ | / | Prognosis | [85] |
| miR-133a-5p | Tissue | ↑ | / | Prognosis | [85] |
| miR-1292-5p | Tissue | ↑ | / | Prognosis | [85] |
| miR-196b-3p | Tissue | ↑ | / | Prognosis | [86] |
| miR-548v | Tissue | ↑ | / | Prognosis | [86] |
| miR-380-3p | Tissue | ↑ | / | Prognosis | [86] |
| miR-1275 | Tissue | ↑ | / | Prognosis | [86] |
| miR126-3p | Tissue | ↑ | / | Prognosis | [87] |
| miR-143-5p | Tissue | ↑ | / | Prognosis | [87] |
| miR-424-5p | Tissue | ↑ | / | Prognosis | [91] |
| let-7a-5p | Tissue | ↑ | / | Prognosis | [91] |
| miR-27a-3p | Tissue | ↑ | / | Prognosis | [91] |
| miR-126-5p | Tissue | ↑ | / | Prognosis | [91] |
| miR-182 | / | ↑ | / | Prognosis | [92] |
| miR-204-5p | Tissue | ↓ | 4-miR:0.94 | Diagnosis | [88] |
| miR-149-5p | Tissue | ↓ | 4-miR:0.94 | Diagnosis | [88] |
| miR-143-3p | Tissue | ↓ | 4-miR:0.94 | Diagnosis | [88] |
| miR-195-5p | Tissue | ↓ | 4-miR:0.94 | Diagnosis | [88] |
| miR-936 | Tissue/Plasma | ↓ | 2-miR:0.73 | Diagnosis | [83] |
| miR-1306-3p | Tissue/Plasma | ↓ | 2-miR:0.73 | Diagnosis | [83] |
| miR-181a | Serum | ↓ | 12-miR:0.848 | Diagnosis | [84] |
| miR-126 | Serum | ↓ | 12-miR:0.848 | Diagnosis | [84] |
| miR-1343-3p | Serum | ↓ | 1.000 | Diagnosis | [93] |
| miR-590-5p | exosomes | ↓ | 0.81 | Diagnosis/Prognosis | [94] |
| miR-92b-5p | Tissue | ↓ | / | Prognosis | [85] |
| miR-942-3p | Tissue | ↓ | / | Prognosis | [85] |
| miR-675-3p | Tissue | ↓ | / | Prognosis | [85] |
| miR-125b-5p | Tissue | ↓ | / | Prognosis | [86] |
| miR-99a-3p | Tissue | ↓ | / | Prognosis | [86] |
| miR-100-5p | Tissue | ↓ | / | Prognosis | [86] |
| miR-363-3p | Tissue | ↓ | / | Prognosis | [86] |
| miR-1275 | Tissue | ↓ | / | Prognosis | [87] |
| miR-23b | Tissue | ↓ | / | Prognosis | [95] |
| miR-194 | Tissue/Cell | ↓ | / | Prognosis | [96] |
| miR-339 | Tissue/Cell | ↓ | / | Prognosis | [97] |
| miR-148a | Plasma | ↓ | / | Prognosis | [98] |
4-miR: AUC values of four miRNA combinations appearing in the same paper, 2-miR: AUC values of two miRNA combinations appearing in the same paper, 12-miR: AUC values of twelve miRNA combinations appearing in the same paper, 3-miR: AUC values of three miRNA combinations appearing in the same paper, ↑: Up-regulated expression, ↓: Down-regulation expression.