Table 4.
MicroRNAs as biomarkers for diagnosis and prognosis of CRC.
| miRNA | Sample | Expression | AUC | Biomarker | Reference |
|---|---|---|---|---|---|
| miR-1290 | Serum | ↑ | 0.7852 | Diagnosis | [89] |
| miR-19a-3p | Serum | ↑ | 0.84 | Diagnosis | [104] |
| miR-203-3p | Serum | ↑ | 0.83 | Diagnosis | [104] |
| miR-221-3p | Serum | ↑ | 0.88 | Diagnosis | [104] |
| let-7f-5p | Serum | ↑ | 0.73 | Diagnosis | [104] |
| miR-21 | Serum/Plasma | ↑ | 0.87 | Diagnosis | [109] |
| let-7e-5p | Plasma/Tissue | ↑ | 4-miR: | Diagnosis | [101] |
| miR-106a-5p | Plasma/Tissue | ↑ | 0.716(Plasma); | Diagnosis | [101] |
| miR-28-3p | Plasma/Tissue | ↑ | 0.998(Tissue) | Diagnosis | [101] |
| miR-542-5p | Plasma/Tissue | ↑ | Diagnosis | [101] | |
| miR-210 | Plasma | ↑ | 2-miR:0.731 | Diagnosis | [103] |
| miR-21 | Plasma | ↑ | 2-miR:0.731 | Diagnosis | [103] |
| miR-203 | Plasma | ↑ | 2-miR:0.833 | Diagnosis | [103] |
| miR-210 | Plasma | ↑ | 2-miR:0.833 | Diagnosis | [103] |
| miR-15b | exosomes | ↑ | 0.82 | Diagnosis | [100] |
| miR-16 | exosomes | ↑ | 0.58 | Diagnosis | [100] |
| miR-21 | exosomes | ↑ | 0.75 | Diagnosis | [100] |
| miR-31 | exosomes | ↑ | 0.75 | Diagnosis | [100] |
| miR-183 | Tissue | ↑ | / | Prognosis | [99] |
| miR-20a | Tissue | ↑ | / | Prognosis | [99] |
| miR-21 | Tissue | ↑ | / | Prognosis | [99] |
| miR-216a-5p | Tissue | ↑ | / | Prognosis | [105] |
| let-7c | Tissue | ↑ | / | Prognosis | [110] |
| let-7e | Tissue | ↑ | / | Prognosis | [110] |
| miR-34c | Tissue | ↑ | / | Prognosis | [110] |
| miR-133b | Tissue | ↑ | / | Prognosis | [110] |
| miR-21-5p | Plasma | ↑ | / | Prognosis | [108] |
| let-7g | exosomes | ↑ | / | Prognosis | [107] |
| miR-96 | Plasma | ↑ | 2-miR:0.93 | Diagnosis/Prognosis | [102] |
| miR-99b | Plasma | ↓ | 2-miR:0.93 | Diagnosis/Prognosis | [102] |
| miR-381-3p | exosomes | ↓ | 2-miR:0.807 | Diagnosis | [111] |
| miR-377-3p | exosomes | ↓ | 2-miR:0.807 | Diagnosis | [111] |
| miR-195 | Tissue | ↓ | / | Prognosis | [99] |
| miRN-139 | Tissue | ↓ | / | Prognosis | [99] |
| miR-145 | Tissue | ↓ | / | Prognosis | [99] |
| miR-194-3p | Tissue | ↓ | / | Prognosis | [105] |
| miR-3677-3p | Tissue | ↓ | / | Prognosis | [105] |
| miR-449a | Tissue | ↓ | / | Prognosis | [106] |
| miR-106a | Tissue | ↓ | / | Prognosis | [110] |
| miR-144 | Tissue | ↓ | / | Prognosis | [110] |
| miR-100 | Tissue | ↓ | / | Prognosis | [112] |
| miR-99a | Tissue | ↓ | / | Prognosis | [112] |
| miR-33b-5p | Tissue | ↓ | / | Prognosis | [113] |
| miR-193a | exosomes | ↓ | / | Prognosis | [107] |
2-miR: AUC values of two miRNA combinations appearing in the same paper, 4-miR: AUC values of four miRNA combinations appearing in the same paper, ↑: Up-regulated expression, ↓: Down-regulation expression.