Table 5.
MicroRNAs as biomarkers for diagnosis and prognosis of BC.
| miRNA | Sample | Expression | AUC | Biomarker | Reference |
|---|---|---|---|---|---|
| let-7b-5p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-106a-5p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-19a-3p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-19b-3p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-20a-5p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-223-3p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-25-3p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-425-5p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-451a | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-92a-3p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-93-5p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-16-5p | Serum/Tissue/exosomes | ↑ | >0.94 | Diagnosis | [125] |
| miR-451a | Serum | ↑ | 6-miR:0.881 | Diagnosis | [126] |
| miR-195-5p | Serum | ↑ | 6-miR:0.881 | Diagnosis | [126] |
| miR-126-5p | Serum | ↑ | 6-miR:0.881 | Diagnosis | [126] |
| miR-30b-5p | Plasma | ↑ | 2-miR:0.9273 | Diagnosis | [116] |
| miR-99a-5p | Plasma | ↑ | 2-miR:0.9273 | Diagnosis | [116] |
| miR-145 | Plasma | ↑ | 4-miR:0.97 | Diagnosis | [117] |
| miR-139-5p | Plasma | ↑ | 4-miR:0.97 | Diagnosis | [117] |
| miR-130a | Plasma | ↑ | 4-miR:0.97 | Diagnosis | [117] |
| miR-425-5p | Plasma | ↑ | 4-miR:0.97 | Diagnosis | [117] |
| pri-miR-526b | Plasma | ↑ | 0.7273 | Diagnosis | [118] |
| miR-19a | Plasma | ↑ | 4-miR:0.802 | Diagnosis | [127] |
| miR-20a | Plasma | ↑ | 4-miR:0.802 | Diagnosis | [127] |
| miR-421 | exosomes | ↑ | 0.835 | Diagnosis | [128] |
| miR-128 | exosomes | ↑ | 0.825 | Diagnosis | [128] |
| miR-16 | EV | ↑ | 4-miR:0.88 | Diagnosis | [119] |
| miR-21 | EV | ↑ | 4-miR:0.88 | Diagnosis | [119] |
| miR-9 | EV | ↑ | 4-miR:0.88 | Diagnosis | [119] |
| miR-429 | EV | ↑ | 4-miR:0.88 | Diagnosis | [119] |
| miR-10b | Tissue | ↑ | / | Prognosis | [53] |
| miR-210 | Tissue | ↑ | / | Prognosis | [121] |
| miR-378c | Tissue | ↑ | / | Prognosis | [122] |
| let-7f-5p | Tissue | ↑ | / | Prognosis | [122] |
| miR-1268b | Tissue | ↑ | / | Prognosis | [122] |
| miR-200c-3p | Tissue | ↑ | / | Prognosis | [122] |
| miR-1271-3p | Tissue | ↑ | / | Prognosis | [122] |
| miR-200c-3p | Tissue | ↑ | / | Prognosis | [123] |
| miR-214-3p | Tissue | ↑ | / | Prognosis | [123] |
| miR-23a-3p | Tissue | ↑ | / | Prognosis | [123] |
| miR-106b-5p | Tissue | ↑ | / | Prognosis | [128] |
| miR-93 | Serum | ↑ | / | Prognosis | [129] |
| miR-210 | Serum | ↑ | / | Prognosis | [129] |
| miR-19a | Serum | ↑ | / | Prognosis | [129] |
| miR-19b | Serum | ↑ | / | Prognosis | [129] |
| miR379/656 cluster | Tissue | ↓ | 0.9843 | Diagnosis/ Prognosis |
[120] |
| miR-423-3p | Serum | ↓ | 6-miR:0.881 | Diagnosis | [126] |
| miR-192-5p | Serum | ↓ | 6-miR:0.881 | Diagnosis | [126] |
| miR-17-5p | Serum | ↓ | 6-miR:0.881 | Diagnosis | [126] |
| miR-126 | Plasma | ↓ | 4-miR:0.802 | Diagnosis | [127] |
| miR-155 | Plasma | ↓ | 4-miR:0.802 | Diagnosis | [127] |
| miR-203 | Tissue | ↓ | / | Prognosis | [53] |
| miR-574 | Tissue | ↓ | / | Prognosis | [121] |
| miR-224 | Tissue | ↓ | / | Prognosis | [121] |
| miR-30b | Tissue | ↓ | / | Prognosis | [121] |
| miR-130a | Tissue | ↓ | / | Prognosis | [121] |
| miR-1200 | Tissue | ↓ | / | Prognosis | [122] |
| miR-1249-3p | Tissue | ↓ | / | Prognosis | [122] |
| miR-1255b-5p | Tissue | ↓ | / | Prognosis | [122] |
| miR-520d | Tissue | ↓ | / | Prognosis | [122] |
| miR-527 | Tissue | ↓ | / | Prognosis | [122] |
| miR-518a-5p | Tissue | ↓ | / | Prognosis | [122] |
| miR-2117 | Tissue | ↓ | / | Prognosis | [122] |
| miR-638 | Tissue | ↓ | / | Prognosis | [123] |
| miR-451a | Tissue | ↓ | / | Prognosis | [123] |
| miR-495-3p | Tissue | ↓ | / | Prognosis | [124] |
| miR-223 | Tissue | ↓ | / | Prognosis | [130] |
| miR-34a | Tissue | ↓ | / | Prognosis | [131] |
| miR-200c | Tissue | ↓ | / | Prognosis | [131] |
| miR-363-5p | Tissue/exosomes | ↓ | / | Prognosis | [132] |
EV: extracellular vesicles, 4-miR: AUC values of four miRNA combinations appearing in the same paper, 2-miR: AUC values of two miRNA combinations appearing in the same paper, 6-miR: AUC values of six miRNA combinations appearing in the same paper, ↑: Up-regulated expression, ↓: Down-regulation expression.