Table 6.
MicroRNAs as biomarkers for diagnosis and prognosis of PCa.
| miRNA | Sample | Expression | AUC | Biomarker | Reference |
|---|---|---|---|---|---|
| miR-3195 | Tissue | ↑ | 3-miR:0.994 | Diagnosis | [139] |
| miR-4417 | Tissue | ↑ | 3-miR:0.994 | Diagnosis | [139] |
| miR-301a | Serum/Tissue | ↑ | / | Diagnosis | [144] |
| miR-4732-3p | Plasma | ↑ | 2-miR:0.8 | Diagnosis | [136] |
| miR-5100 | Plasma | ↑ | / | Diagnosis | [135] |
| miR-1255-5p | Plasma | ↑ | 0.885 | Diagnosis | [145] |
| miR-181a-5p | exosomes | ↑ | 0.738 | Diagnosis | [138] |
| miR-451a | Urine exosomes | ↑ | 0.757 | Diagnosis | [146] |
| miR-486-3p | Urine exosomes | ↑ | 0.704 | Diagnosis | [146] |
| miR-486-5p | Urine exosomes | ↑ | 0.796 | Diagnosis | [146] |
| miR-6078 | Urine | ↑ | 0.7 | Diagnosis | [137] |
| miR-1913 | Urine | ↑ | 2-miR:0.821 | Diagnosis | [147] |
| miR-3659 | Urine | ↑ | 2-miR:0.821 | Diagnosis | [147] |
| miR-451a | SEVs | ↑ | 0.65 | Diagnosis | [148] |
| miR-141 | SEVs | ↑ | 0.64 | Diagnosis | [148] |
| miR-145 | SEVs | ↑ | 0.76 | Diagnosis | [148] |
| miR-221 | SEVs | ↑ | 0.7 | Diagnosis | [148] |
| miR-17-5p | Tissue | ↑ | / | Prognosis | [140] |
| miR-222-3p | Tissue | ↑ | / | Prognosis | [142] |
| miR-582-5p | Tissue | ↑ | / | Prognosis | [142] |
| miR-582-3p | Tissue | ↑ | / | Prognosis | [142] |
| miR-505-3p | Tissue | ↑ | / | Prognosis | [142] |
| miR-326 | Tissue | ↑ | / | Prognosis | [142] |
| miR-212-3p | Tissue | ↑ | / | Prognosis | [142] |
| miR-296-5p | Tissue | ↑ | / | Prognosis | [142] |
| miR-144-3p | Tissue | ↑ | / | Prognosis | [142] |
| miR-532-5p | Urine exosomes | ↑ | / | Prognosis | [143] |
| miR-425-5p | Cell exosomes | ↑ | / | Prognosis | [149] |
| miR-205 | Tissue | ↓ | 3-miR:0.994 | Diagnosis | [139] |
| miR-26b-5p | Plasma | ↓ | 2-miR:0.944 | Diagnosis | [136] |
| miR-98-5p | Plasma | ↓ | 2-miR:0.944 | Diagnosis | [136] |
| miR-26b-5p | Plasma | ↓ | 2-miR:0.8 | Diagnosis | [136] |
| miR-15a-5p | Urine | ↓ | 0.71 | Diagnosis | [137] |
| miR-3126-3p | Urine | ↓ | 0.76 | Diagnosis | [137] |
| miR-324-5p | Urine | ↓ | 0.74 | Diagnosis | [137] |
| miR-150-5p | Urine | ↓ | 0.76 | Diagnosis | [137] |
| miR-425-3p | Urine | ↓ | 0.71 | Diagnosis | [137] |
| miR-375 | Urine exosomes | ↓ | 0.788 | Diagnosis | [146] |
| miR-199b-3p | Tissue | ↓ | / | Prognosis | [141] |
| miR-21-5p | Tissue | ↓ | / | Prognosis | [142] |
| miR-192-5p | Tissue | ↓ | / | Prognosis | [142] |
| miR-15b-5p | Tissue | ↓ | / | Prognosis | [142] |
| miR-106b-5p | Tissue | ↓ | / | Prognosis | [142] |
| miR181a-5p | Tissue | ↓ | / | Prognosis | [142] |
| miR-18a-5p | Tissue | ↓ | / | Prognosis | [142] |
| miR-301a-3p | Tissue | ↓ | / | Prognosis | [142] |
SEVs: small extracellular vesicles, 2-miR: AUC values of two miRNA combinations appearing in the same paper, 3-miR: AUC values of three miRNA combinations appearing in the same paper, ↑: Up-regulated expression, ↓: Down-regulation expression.