Table 2.

List of microbes differentially abundant across LUAD and LUSC samples. Corresponding p-Value denoting significance of relationship.

Cancer	Microbe	Diagnosis Age	Sex	Race	Smoking History	Pathologic Stage	Neoplasm Presence	Therapy Outcome
LUAD	Aeropyrum pernix	0.000339				0.027172
	Caldivirga maquilingensis					0.01464
	Candidatus Nitrosarchaeum limnium BG20	0.012235			0.011974
	Candidatus Nitrosocosmicus oleophilus	0.000243	0.026028
	Candidatus Nitrososphaera gargensis					0.026028
	Desulfurococcus amylolyticus 1221n					0.034768
	Halogeometricum borinquense DSM 11551		0.015319
	Halorhabdus tiamatea SARL4B	0.047583
	Infirmifilum uzonense				0.003069
	Metallosphaera yellowstonensis MK1				0.036199
	Methanobacterium kanagiense			0.029399
	Methanocaldococcus infernus ME		0.022004
	Methanocella arvoryzae MRE50	0.047327
	Methanococcus aeolicus				0.002794
	Methanococcus maripaludis S2	0.001452
	Methanococcus vannielii SB	0.001327
	Methanoculleus marisnigri JR1	1.42 ×10−8		0.000996
	Methanopyrus kandleri AV19		0.024732		0.007884
	Methanosaeta harundinacea 6Ac	0.000167
	Methanosarcina siciliae HI350			0.041515
	Methanothermobacter thermautotrophicus	0.001041
	Natrialba magadii ATCC 43099	0.022468
	Natrinema pellirubrum DSM 15624	8.59 × 10−12
	Pyrobaculum islandicum					0.016035	0.046881	0.000782
	Pyrodictium brockii			0.044358
	Pyrolobus fumarii 1A			0.037196		0.025456
	Thermofilum adornatus 1505				0.037196
	Thermofilum pendens Hrk 5	0.000006
	Thermoplasma volcanium GSS1	0.042784
	Thermoplasmatales archaeon BRNA1				0.02283
	Thermoproteus uzoniensis					0.016035	0.046881	0.000782
	Thermosphaera aggregans DSM 11486	5.79 × 10−7
	uncultured crenarchaeote					0.045191	0.010931
	uncultured Methanobacteriales archaeon	0.007569
	uncultured methanogenic archaeon			0.002368	0.009116
	uncultured Nitrosopumilales archaeon	0.00077						0.032531
	Vulcanisaeta distributa DSM 14429	0.000003
LUSC	Aeropyrum pernix						0.030009
	Desulfurococcus amylolyticus 1221n	0.006251
	Desulfurococcus amylolyticus DSM 16532	0.002899
	Haloarcula sp CBA1115							0.00029
	Halorhabdus tiamatea SARL4B				0.005232
	Metallosphaera yellowstonensis MK1	0.032987
	Methanobacterium formicicum							0.042146
	Methanocaldococcus infernus ME						0.007339
	Methanococcus maripaludis X1	7.02 × 10−24
	Methanopyrus kandleri AV19	0.018165
	Methanosarcina barkeri CM1	0.013269					0.011716
	Methanothermococcus okinawensis IH1							0.024171
	Methanothermus fervidus DSM 2088	0.007446				0.034249
	Thermoplasmatales archaeon BRNA1					0.014448
	uncultured Candidatus Thalassoarchaea					0.015503
	euryarchaeote
	uncultured crenarchaeote	0.02786
	uncultured Methanosarcinales archaeon			0.001505
	uncultured Thermoprotei archaeon				0.047705