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. 2022 Sep 26;23(19):11340. doi: 10.3390/ijms231911340

Figure 3.

Figure 3

Synergistic effect of combined treatment of pentadecanoic acid and tamoxifen in MCF−7/SC cells. Cell viability was assessed using the MTT assay with pentadecanoic treatment alone or in combination with tamoxifen (0 μM, 5 μM, and 10 μM) at (A) 24 h and (B) 48 h. CI values were calculated after combined treatment at (C) 24 h and (D) 48 h in MCF−7/SC cells. Effects of pentadecanoic acid and tamoxifen treatment alone at 5 µM (E,F) and 10 µM (G,H) or their combination on colony formation of MCF−7/SC cells. The asterisk (*) indicates p < 0.05 vs. the control. The hash mark (#) indicates p < 0.05 when comparing combined treatment vs. individual treatment. PDCN: pentadecanoic acid; Tam: tamoxifen. The CI values illustrated in the graph are the mean from three independent experiments. Data are representative of three biologically independent experiments and values are shown in mean ± SD.