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. 2022 Sep 26;23(19):11340. doi: 10.3390/ijms231911340

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pentadecanoic acid combined with tamoxifen inhibited survival−associated signaling pathways. (A) KEGG analysis was used to analyze the enrichment of common survival pathways in MCF−7/SC cells compared to those in MCF−7 cells. The levels of proteins related to ERK1/2, MAPK, EGFR, and mTOR signaling compared between MCF−7 and MCF−7/SC (B,C) cells or following pentadecanoic acid or combined treatment for 48 h in MCF−7/SC cells (D,E). β−actin was used as a loading control. The asterisk (*) indicates p < 0.05 vs. the control. The hash mark (#) indicates p < 0.05 when comparing the combined vs. individual treatments. Data are representative of three biologically independent experiments and values are shown in mean ± SD.

Pentadecanoic acid combined with tamoxifen inhibited survival−associated signaling pathways. (A) KEGG analysis was used to analyze the enrichment of common survival pathways in MCF−7/SC cells compared to those in MCF−7 cells. The levels of proteins related to ERK1/2, MAPK, EGFR, and mTOR signaling compared between MCF−7 and MCF−7/SC (B,C) cells or following pentadecanoic acid or combined treatment for 48 h in MCF−7/SC cells (D,E). β−actin was used as a loading control. The asterisk (*) indicates p < 0.05 vs. the control. The hash mark (#) indicates p < 0.05 when comparing the combined vs. individual treatments. Data are representative of three biologically independent experiments and values are shown in mean ± SD.