Figure 6.
PEG2-induced pyroptosis pathways and invasion of EMS lesion in vivo. (a) After intervention with PGE2 in endometriosis mouse model, ectopic lesions were enlarged. Ectopic lesions obtained from endometriosis mice after continuous treatment with PGE2. The volume of ectopic lesions was statistically analyzed (** p < 0.05); (b) immunohistochemistry showed that NLRP3, cleaved caspase-1, Il-1β, Il-18, HMGB1 and Vimentin were highly expressed in the endometrial tissues of mice treated with PGE2.E-cadherin was down-regulated in the endometrial tissues of mice treated with PGE2 (** p < 0.05).