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. 2022 Oct 8;23(19):11939. doi: 10.3390/ijms231911939

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Values of predicted concentrations with and without PK interaction for (a) siremadlin and (b) trametinib in spleen tissue; (c) siremadlin and (d) trametinib in A375 tumour tissue; observed data are means from n = 3.

Values of predicted concentrations with and without PK interaction for (a) siremadlin and (b) trametinib in spleen tissue; (c) siremadlin and (d) trametinib in A375 tumour tissue; observed data are means from n = 3.