Table 1.
CaMKK in eukaryotic species.
| CaMKK | Species | UniProtKB | M.M. (Da) | Ca2+/CaM | Substrates | |
|---|---|---|---|---|---|---|
| (a.a. Residues) | -Dependency | (Phosphorylation Site) | ||||
| CaMKKα/1 | rat | P97756 | 55,908 (505) [20] | YES [25] | CaMKI (α: Thr177) [20,26] | |
| mouse | Q8VBY2 | 55,838 (505) | CaMKIV (Thr196) [20,25] | |||
| human | Q8N5S9 | 55,735 (505) | PKB/Akt (Thr308) [27] | |||
| BRSK1 (Thr189) [28,29] | ||||||
| Syndapin I (Thr355) [30] | ||||||
| CaMKKβ/2 | rat | O88831 | 64,446 (587) [21,22] | YES [22] | CaMKI (α: Thr177) [22] | |
| mouse | Q8C078 | 64,618 (588) | (autonomous activity) [22,31] | CaMKIV (Thr196) [21,22] | ||
| –1 | human | Q96RR4-1 | 64.746 (588) [22] | PKB/Akt (Thr308) [32] | ||
| –2 | human | Q96RR4-2 | 58,899 (533) [23] | AMPK (α: Thr172) [33,34,35] | ||
| –3 | human | Q96RR4-3 | 59,602 (541) [24] | SIRT1 (Ser27, Ser47) [36] | ||
| GAPDH, Pex3 [37] | ||||||
| CKK-1 [38] | –a | C. elegans | Q3Y416-2 | 48,940 (432) | YES [39] | CMK1 (Thr179) [40] |
| –b | C. elegans | Q3Y416-1 | 60,804 (541) | |||
| CMKC [41] | A. nidulans | Q9Y898 | 59,153 (518) | YES | CMKB (Thr179) [41] | |
| Ssp1 [42] | S. pombe | P50526 | 73,992 (652) | ND | Ssp2 (Thr189) [42,43] |
M.M.; molecular mass, a.a.; amino acid, ND; not determined.