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. 2022 Sep 28;23(19):11467. doi: 10.3390/ijms231911467

Figure 7.

Figure 7

ZnT2 is vital for lysosome biogenesis and the activation of autophagy in colonocytes during infectious colitis in mice. (A) Representative images of LAMP1 (red) in the colon of WT (i) and ZnT2-null (KO; ii) mice. Magnification ×20; scale bars = 50 µm. Representative images of LAMP1 (red) in the colons from WT mice pre-infection (iii), and 10 (iv) and 21 (v) days post-infection and KO mice pre-infection (vi), and 10 (vii) and 21 (viii) days post-infection. Magnification ×4; Scale bars = 1 mm. (B) Data represent mean number of lysosomes/crypt ± SD; n = 25–36 crypts from 3 mice/genotype; *** p < 0.001. (C) Data represent mean number of lysosomes/crypt in WT mice pre-infection (d0), and 10 (d10) and 21 (d21) post-infection ± SD; n = 20–36 crypts from 3 mice/genotype; *** p < 0.001. (D) Data represent mean number of lysosomes/crypt in KO mice pre-infection (d0), and 10 (d10) and 21 (d21) post-infection ± SD; n = 18–25 crypts from 3 mice/genotype.