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. 2022 Sep 29;23(19):11528. doi: 10.3390/ijms231911528

Scheme 2.

Scheme 2

Synthesis of the B series of TMA analogs. Reaction conditions: a. Ethyl acetoacetate, H2SO4, 1 h, 82%; b. Chloroacetone, K2CO3, KI, acetone, reflux, 12 h, 69%; c. KOH, EtOH abs., reflux, 1 h, 34%; d. Arylboronic acid, Na2CO3, Pd(PPh3)4, DME, reflux, 2 h, 33–76%. See Table 2 for the R specification.