Figure 1.
(Ai)-(Aiii). Correlations between platelet surface-associated CXCL16, platelet-CXCR6, and serum levels of soluble (s)CXCL16 in CAD patients. (Bi)–(Biii). Correlations between platelet-CXCL16, platelet-CXCR6, serum levels of soluble CXCL16 in CAD patients, and Mean platelet volume (MPV). (Biv). Correlation between serum sCXCL16 and circulatory platelet count (Plts = Platelet count × 103/µL) in CAD patients. Correlations were assessed by Spearman’s rank correlation coefficient (ρ); p: level of significance; MFI: mean fluorescence intensity. (C). Schematic diagram depicting platelets as a potential source of sCXCL16 generated by the proteolytic cleavage of the transmembrane-SR-PSOX/CXCL16 by ADAM10. The sCXCL16 may engage its cognate receptor CXCR6 on platelets to elicit pro-thrombotic effects.