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. 2022 Sep 20;23(19):11013. doi: 10.3390/ijms231911013

Figure 3.

Figure 3

The effect of ADAM10 inhibitor (GI254023X) or ADAM17 inhibitor (TAPI-1) on constitutively and LPS-induced BV2 microglial phagocytosis activity. BV2 microglial cells were incubated with GI254023X (1 and 5 μM) or TAPI-1 (5 and 25 μM) for 24 h in the absence or presence of 1000 ng/mL LPS. (A) The effect of GI254023X treatment on BV2 microglial phagocytosis activity. (B) The effect of TAPI-1 treatment on BV2 microglial phagocytosis activity. Black: constitutive phagocytes set on 1; red: LPS-induced phagocytosis; blue: effect of ADAMs inhibitor on constitutive phagocytosis; green: effect of ADAMs inhibitor on LPS-induced phagocytosis. Results were expressed as mean ± SEM. n = 4 from 4 independent experiments. * p < 0.05, ** p < 0.01, **** p < 0.0001.