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. 2022 Sep 24;23(19):11255. doi: 10.3390/ijms231911255

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The alteration of the inflammatory response and AhR over the spinal dorsal root ganglion in a CCI model modulated by AhR. Either wild or AhR-deleted mouse received CCI injuries and then were subjected to omeprazole treatment. The dorsal root ganglion was obtained for the analysis 28 days after CCI. (A) Expression of NGF in the different treatment groups. (B) Expression of TNF-α in the different treatment groups. (C) Expression of synaptophysin in the different treatment groups. (D) Expression of AhR in the different treatment groups. Bar length = 100 μm; N = 6; Wild type-sham; Wild type-CCI; AhR (−/−)-CCI; Wild type-CCI-omeprazole: see text.