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. 2022 Oct 3;23(19):11712. doi: 10.3390/ijms231911712

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Molecular mechanism represents the role of kaempferol in epigenetic modulation during cancer and how it protects from cancer. Kaempferol protecting against cancer via a different mechanism such as inhibition of DNMT3B which prematurely degrades and blocks proteasome with MGI32 further causes autophagy via G9a inhibition and ubiquitin-mediated proteolysis; on the other hand, reactivated DACT2 inhibits Wnt-β-catenin signaling pathway and leads to impairment of the CRC cell proliferation and migration further causes epigenetic modulation and protects against cancer; increased localization of the IRE-JNK CHOP from cytosolic to the nucleus further inhibits G9a; decreased DACT2 methylation; increased unmethylated DACT2 binds directly to DNA methyltransferase DNMT1 and is involved in epigenetic modulation during cancer.