Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 3;23(19):11712. doi: 10.3390/ijms231911712

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Gallic acid protects from cancer. Gallic acid suppresses cell viability, proliferation, invasion, and angiogenesis; reactivates growth arrest and GADD45; increases demethylation and increases the DNMT1, DNMT3A, and DNMT3B found to be more in the nucleus; decreases HDAC1 and 2; increases acetyl-p53; decreases PCNA; cyclin D and E; up-regulation of p21, decreases BAX, Cas3, and PARP, and increases Bcl2; inhibits P300/CBP-dependent HAT activation; P300-p65 inhibition; cytosolic IKBα; inhibition of NF-kB; and further protects from cancer.