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Quercetin protects from cancer via an epigenetic mechanism. Quercetin inhibits NF-kB acetylation by p300 HAT; decreases cyclin D; increases Fas L via H3 acetylation; increases P161NK4a via promoter demethylation; decreases DNMT1 and DNMT3a; DNA methylation HDAC inhibition, H3AC, and H4AC, and increases apoptosis; inhibits the transcriptional CREBP2, c-Jun, CEBP; P300 and NF-kB.
