Table 2.

Odd ratios (OR) associated with the variable selected in the LASSO models constructed from the candidate oxylipins and/or the MetS criteria. Two new LASSO models were constructed with the participants in the Discovery study using either only the 5 criteria of MetS (i.e., waist circumference, blood pressure, fasting glucose, triglycerides and HDLc, LASSO model N°2, “–” for not applicable for this model) or the 5 criteria of MetS and the 23 candidate oxylipins (column 3, LASSO model N°3). Of note, the 5 MetS criteria were the criteria of selection of MetS participants. The predictive performance of these two LASSO models reached a cross-validated AUC of 93% (95% CI: 90–96%) and 95% (95% CI: 90–96%), respectively. Six candidate oxylipins (i.e., 9(10)-Ep-stearic acid, 12-HETrE, 7-HDHA, 9,10-DiHOME, 9,10-DiHODE and 9(10)-EpOME) out of the 23 provided were not selected in the LASSO model N°3.

	Odd Ratios Associated with the Variables Selected in the LASSO Models
	LASSO Model N°2 (using only the 5 MetS criteria)	LASSO Model N°3 (using both the 23 candidate oxylipins and the 5 MetS criteria)
TG	1.13	1.11
SBP	1.04	1.02
DBP	1.02	1.04
Waist circumference	1.18	1.13
Fasting glucose	1.15	1.10
HDLc	0.96	0.96
8-HEPE	–	1.53
16-HETE	–	1.16
12(13)-EpODE	–	1.01
5-HETE	–	0.11
9-HODE	–	1.01
14,15-DiHETrE	–	1.02
5-HETrE	–	0.95
15-HODE	–	0.96
13-oxo-ODE	–	0.93
11(12)-EpETrE	–	0.95
9-oxo-ODE	–	1.01
4-HDHA	–	0.92
13-HODE	–	0.95
12-HODE	–	0.91
7,8-DiHDPE	–	0.96
15-HETE	–	0.86
5-HEPE	–	0.71