Table 3.
Methodological Quality of Studies using the SYRCLE strategy.
| Study | Q1 | Q2 | Q3 | Q4 | Q5 | Q6 | Q7 | Q8 | Q9 | Q10 | Score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ali et al., 2019 [13] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Arranz et al., 2010 [14] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Brod et al., 2017 [15] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Ferré et al., 2016 [16] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Gurfein et al., 2017 [17] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Keymoradzadeh et al., 2020 [18] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Marashi et al., 2003 [19] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| McQuaid et al., 2013 [20] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Meng et al., 2018 [21] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Rattazi et al., 2016 [22] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Takai et al., 2019 [10] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Wang et al., 2018 [23] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Williamson et al., 2012 [24] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Zarif et al., 2017 [25] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
| Zhang et al., 2017 [26] | U | Y | Y | Y | N | Y | U | U | Y | Y | 6 |
Notes: Q1: Was the allocation sequence adequately generated and applied? Q2: Were the groups similar at baseline or were they adjusted for confounders in the analysis? Q3: Was the allocation to the different groups adequately concealed during? Q4: Were the animals randomly housed during the experiment? Q5: Were the caregivers and/or investigators blinded from knowledge of which intervention each animal received during the experiment? Q6: Were the animals selected at random for the outcome assessment? Q7: Was the outcome assessor blinded? Q8: Were incomplete outcome data adequately addressed? Q9: Are reports of the study free of selective outcome reporting? Q10: Was the study apparently free of other problems that could result in high risk of bias? Unclear; Y: Yes; N: No.