Figure 5.
Chemical structure of propargylamine derivatives. (A) 8-Hydroxyquinone derivatives of rasagiline (HLA-20, M30) inhibit MAO-B and chelate metals. (B) Propargyl derivatives of rivastigmine (TV3326, TV3279) inhibit ChE and MAO-B with a carbamate moiety and exert neuroprotection by a propargylamine moiety. (C) Propargylamine derivatives of donepezil. (D) Indanone derivatives of rasagiline are H3 receptor agonists, inhibit MAO, and improve cognitive functions. (E) N-Methyl-phenyl-selegiline inhibits MAO-B, chelates copper (II), iron (II), and zinc (II), and inhibits Aβ1–42 aggregates.