Table 1.

Cytotoxic efficacy of selected compounds assessed by MTT assays. IC₅₀ values of the assessed compounds in the luminal A cell line MCF-7 and TNBC cell lines (mean ± SEM). PTX (in gray) was used as a reference compound.

Drugs	IC50 Values (µM, Mean ± SEM)
	MCF-7	MDA-MB-231	HCC-1806	MDA-MB-468	BT-549	BT-20
PTX	0.012 ± 0.003	1.473 ± 0.014	0.008 ± 0.002	0.004 ± 0.001	0.015 ± 0.007	0.012 ± 0.004
YM	0.019 ± 0.004	0.004 ± 0.001	0.018 ± 0.002	0.002 ± 0.001	0.025 ± 0.001	0.001 ± 0.001
PNB	0.058 ± 0.022	0.084 ± 0.014	0.016 ± 0.004	0.002 ± 0.001	0.144 ± 0.007	0.084 ± 0.032
VS	0.193 ± 0.078	9.365 ± 4.329	---	---	---	---
NCS *	0.373 ± 0.097	0.545 ± 0.024	3.106 ± 0.101	1.878 ± 0.458	0.960 ± 0.034	1.547 ± 0.062
FLU	0.787 ± 0.110	17.87 ± 1.300	0.402 ± 0.130	0.001 ± 0.001	0.504 ± 0.049	0.041 ± 0.003
NTC	1.055 ± 0.166	1.314 ± 0.159	---	---	---	---
DSF	1.182 ± 0.152	11.65 ± 0.253	---	---	---	---
SAL *	2.702 ± 0.107	0.399 ± 0.149	---	---	---	---
DFT	3.242 ± 1.180	32.10 ± 1.720	---	---	---	---
8Q *	4.442 ± 0.137	25.55 ± 0.151	25.19 ± 1.08	3.295 ± 0.111	79.74 ± 2.890	16.15 ± 0.67
EVE	10.38 ± 0.591	13.21 ± 1.449	---	---	---	---
GLA	21.71 ± 4.367	18.72 ± 5.362	---	---	---	---
ISO	25.11 ± 0.724	53.33 ± 5.275	---	---	---	---
6-SHO	27.73 ± 1.597	24.08 ± 2.995	---	---	---	---
MET	3523 ± 601	3315 ± 396	---	---	---	---
ACE	4670 ± 417	6806 ± 842	---	---	---	---
CIT	>200	>200	---	---	---	---

Drug abbreviations stand for: PTX, paclitaxel; YM, YM-155 hydrocloride; PNB, panobinostat; VS, VS-5584; NCS, niclosamide; FLU, flubendazole; NTC, nitidine chloride; DSF, disulfiram; SAL, salimomycin; DFT, defactinib; 8Q, 8-quinolinol; EVE, everolimus; GLA, glabridin; ISO, isoliquiritigenin; 6-SHO, 6-shogaol; MET, metformin hydrochloride; ACE, acetaminophen; CIT, citral. Compounds proceeding into further assays are labeled with an asterisk *.