Table 2.
Cytostatic activity of polyanhydrides against various cancer cell lines, expressed as IC50 a.
| Compound | Cytostatic Activity IC50 [µg/mL] | ||||
|---|---|---|---|---|---|
| HeLa | U-87 MG | KB | MCF-7 | A549 | |
| DBB b | 8.25 ± 0.81 | 7.37 ± 0.26 | 7.17 ± 0.93 | 7.25 ± 0.79 | 7.09 ± 0.01 |
| polyDBB b | 16.23 ± 0.72 | 16.07 ± 0.02 | 17.81 ± 0.03 | 13.38 ± 0.06 | 16.19 ± 0.31 |
| DBB_PEG_COOH_5 | 4.99 ± 0.06 | 4.08 ± 0.03 | 4.11 ± 0.01 | 4.51 ± 0.03 | 4.12 ± 0.01 |
| DBB_ PEG _COOH_10 | 4.92 ± 0.04 | 4.16 ± 0.08 | 4.48 ± 0.02 | 4.05 ± 0.22 | 4.72 ± 0.03 |
| DBB_ PEG _COOH_20 | 3.88 ± 0.01 | 3.87 ± 0.01 | 3.08 ± 0.07 | 3.82 ± 0.05 | 3.84 ± 0.01 |
| DBB_ PEG _COOH_30 | 6.04 ± 0.08 | 6.77 ± 0.04 | 6.93 ± 0.03 | 6.04 ± 0.11 | 6.31 ± 0.03 |
| DBB_ PEG _COOH_40 | 4.97 ± 0.04 | 5.13 ± 0.02 | 5.59 ± 0.01 | 5.94 ± 0.07 | 5.09 ± 0.02 |
| DBB_ PEG _COOH_50 | 6.99 ± 0.06 | 6.74 ± 0.01 | 6.29 ± 0.01 | 6.88 ± 0.09 | 6.26 ± 0.03 |
| DBB_ PEG _COOH_60 | 8.04 ± 0.05 | 8.11 ± 0.07 | 8.74 ± 0.02 | 8.05 ± 0.01 | 8.75 ± 0.12 |
| DBB_ PEG _COOH_70 | 8.73 ± 0.02 | 8.28 ± 0.03 | 8.14 ± 0.12 | 8.09 ± 0.01 | 8.44 ± 0.09 |
| DBB_ PEG _COOH_80 | 12.08 ± 0.06 | 12.77 ± 0.11 | 12.43 ± 0.17 | 12.99 ± 0.03 | 12.41 ± 0.03 |
| PEG_COOH | 36.07 ± 0.11 | 36.94 ± 0.93 | 36.12 ± 0.19 | - | 36.56 ± 0.76 |
| Cytarabine c | 1.40 ± 0.08 | 1.03 ± 0.25 | 0.95 ± 0.02 | - | 1.17 ± 0.21 |
a N = 3 (t-test), p < 0.05. b results from our previous work c Cytarabine and actinomycin D were used as the standard.