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. 2022 Oct 4;23(19):11781. doi: 10.3390/ijms231911781

Figure 2.

Figure 2

Examples of IGF-targeted agents. Anti-IGF-1R mAbs block ligand–receptor interactions and induce receptor internalization and degradation. Tyrosine kinase inhibitors bind to the receptor tyrosine kinase domain and block the downstream signaling of IGF-1R and INSR. IGF ligand-neutralizing mAbs bind to both IGF ligands (IGF-1 and IGF-2), thereby blocking the activation of IGF-1R and INSR-A. IGF-1R, insulin-like growth factor-1 receptor; mAbs, monoclonal antibodies; TKI, tyrosine kinase inhibitors; INSR, insulin receptor.