Figure 1.

Changes that occur in mitochondria due to aging or aging related disorders are associated with a reduction in the function of mitochondria. Due to the accumulation of mutations and the oxidative damage generated by reactive oxygen species (ROS), the mitochondrial DNA volume, integrity, and functionality all decline with advanced. Left Panel represents young individuals with balanced homeostasis leading to normal biological functions of tissues. Right Panel represents greater levels of oxidative stress that lead to increased ROS and mitochondrial dysfunction along with abnormal biological functions.