Table 2.
Differentially expressed miRNAs in BCRL cases compared to HCs revealed by small RNA-sequencing. The FDR-adjusted p-value (Benjamini–Hochberg), p < 0.05 was considered statistically significant.
| miRNA | Average Read Counts | p-Value | FDR-adj p-Value | Log2 FC | FC | |
|---|---|---|---|---|---|---|
| BCRL | HC | |||||
| hsa-miR-3613-5p | 113.182 | 369.874 | 3.83 × 10−8 | 1.54 × 10−5 | −1.708 | 0.306 |
| hsa-miR-144-5p | 57.294 | 173.178 | 6.96 × 10−5 | 4.66 × 10−3 | −1.596 | 0.331 |
| hsa-miR-206 | 9.864 | 29.701 | 3.32 × 10−3 | 3.81 × 10−2 | −1.590 | 0.332 |
| hsa-miR-676-5p | 3.988 | 10.401 | 6.60 × 10−4 | 1.56 × 10−2 | −1.383 | 0.383 |
| hsa-miR-6804-5p | 11.032 | 28.050 | 2.66 × 10−4 | 1.07 × 10−2 | −1.346 | 0.393 |
| hsa-miR-3122 | 8.868 | 21.873 | 5.50 × 10−3 | 4.91 × 10−2 | −1.302 | 0.405 |
| hsa-miR-3943 | 8.738 | 21.506 | 1.39 × 10−4 | 7.05 × 10−3 | −1.299 | 0.406 |
| hsa-miR-4785 | 4.925 | 10.897 | 4.45 × 10−3 | 4.59 × 10−2 | −1.146 | 0.452 |
| hsa-miR-7-5p | 64.671 | 137.452 | 8.82 × 10−4 | 1.77 × 10−2 | −1.088 | 0.471 |
| hsa-miR-27a-5p | 12.987 | 26.987 | 2.30 × 10−3 | 2.99 × 10−2 | −1.055 | 0.481 |
| hsa-miR-423-3p | 602.444 | 294.668 | 4.36 × 10−4 | 1.46 × 10−2 | 1.032 | 2.044 |
| hsa-miR-199b-3p | 402.345 | 194.458 | 2.18 × 10−3 | 2.92 × 10−2 | 1.049 | 2.069 |
| hsa-miR-584-5p | 899.623 | 424.343 | 6.30 × 10−4 | 1.56 × 10−2 | 1.084 | 2.120 |
| hsa-miR-1908-5p | 60.460 | 28.355 | 4.76 × 10−3 | 4.73 × 10−2 | 1.092 | 2.132 |
| hsa-miR-199a-3p | 2601.828 | 1168.249 | 5.40 × 10−3 | 4.91 × 10−2 | 1.155 | 2.227 |
| hsa-miR-139-3p | 49.942 | 22.281 | 1.99 × 10−3 | 2.86 × 10−2 | 1.164 | 2.241 |
| hsa-miR-625-5p | 76.687 | 33.298 | 9.70 × 10−4 | 1.86 × 10−2 | 1.204 | 2.303 |
| hsa-miR-28-5p | 27.377 | 11.869 | 3.22 × 10−3 | 3.81 × 10−2 | 1.206 | 2.307 |
| hsa-miR-1301-3p | 51.522 | 21.774 | 6.71 × 10−4 | 1.56 × 10−2 | 1.243 | 2.366 |
| hsa-miR-328-3p | 124.036 | 52.264 | 1.12 × 10−3 | 2.05 × 10−2 | 1.247 | 2.373 |
| hsa-miR-1307-3p | 309.259 | 129.059 | 1.46 × 10−4 | 7.05 × 10−3 | 1.261 | 2.396 |
| hsa-miR-151b/151a-5p | 217.733 | 89.353 | 6.80 × 10−4 | 1.56 × 10−2 | 1.285 | 2.437 |
| hsa-miR-326 | 50.869 | 20.848 | 1.98 × 10−3 | 2.86 × 10−2 | 1.287 | 2.440 |
| hsa-miR-744-5p | 248.133 | 101.532 | 4.87 × 10−4 | 1.50 × 10−2 | 1.289 | 2.444 |
| hsa-miR-6126 | 121.629 | 46.948 | 1.59 × 10−3 | 2.62 × 10−2 | 1.373 | 2.591 |
| hsa-miR-6872-3p | 45.793 | 17.625 | 5.05 × 10−3 | 4.83 × 10−2 | 1.377 | 2.598 |
| hsa-miR-151a-3p | 2350.841 | 847.293 | 2.59 × 10−7 | 5.20 × 10−5 | 1.472 | 2.775 |
| hsa-miR-370-3p | 109.725 | 37.192 | 1.79 × 10−3 | 2.76 × 10−2 | 1.561 | 2.950 |
| hsa-miR-382-5p | 324.453 | 102.653 | 2.75 × 10−3 | 3.45 × 10−2 | 1.660 | 3.161 |
| hsa-miR-199a-5p | 77.776 | 22.796 | 7.49 × 10−6 | 1.00 × 10−3 | 1.771 | 3.412 |
| hsa-miR-409-3p | 251.053 | 72.922 | 1.25 × 10−3 | 2.18 × 10−2 | 1.784 | 3.443 |
| hsa-miR-134-5p | 119.347 | 33.867 | 6.99 × 10−4 | 1.56 × 10−2 | 1.817 | 3.524 |
| hsa-miR-432-5p | 521.532 | 132.257 | 7.92 × 10−4 | 1.68 × 10−2 | 1.979 | 3.943 |
| hsa-miR-3135b | 234.283 | 59.139 | 3.64 × 10−5 | 3.00 × 10−3 | 1.986 | 3.962 |
| hsa-miR-4784 | 145.818 | 36.234 | 3.73 × 10−5 | 3.00 × 10−3 | 2.009 | 4.024 |
| hsa-miR-431-5p | 205.717 | 39.445 | 1.58 × 10−4 | 7.05 × 10−3 | 2.383 | 5.215 |