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. 2022 Oct 4;23(19):11770. doi: 10.3390/ijms231911770

Figure 9.

Figure 9

Hyperammonemia increases the content of gephyrin and the phosphorylation of the β3 subunit of the GABAA receptor in the cerebellum. This is reversed by blocking TrkB, TNFR1, S1PR2 or CCR2. (A–D) Gephyrin content and (E–H) the phosphorylation of the β3 subunit of the GABAA receptor in the cerebellum of control (C) and hyperammonemic (HA) rats were analyzed with Western blot. The effects of blocking TrkB with ANA12, TNFR1 with R7050, S1PR2 with JTE-013, or CCR2 with RS504393 on the content are also shown. Values are the mean ± SEM of 15–20 rats per group. Values significantly different from control rats are indicated with asterisks, and from hyperammonemic rats are indicated with “a”. * p < 0.05, *** p < 0.001, **** p < 0.0001; a p < 0.05, aa p < 0.01, aaaa p < 0.0001. (A–H) F values were 10.13, 12.54, 13.19, 14.37, 4.059, 12.25, 4.927, and 4.183, respectively. Data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test.