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. 2022 Oct 10;23(19):12017. doi: 10.3390/ijms231912017

Figure 1.

Figure 1

Figure 1

A sequential excluding of the study confounder- and medication-dependent lipids. (A) A Venn diagram illustrating the common set of lipids dysregulated due to LBMD (n = 345) after excluding the significant confounder effects including gender, thyroid disease (TD), and body mass index (BMI) (n = 703) T2DM and FBG (n = 880)], patients’ lipid profiles (n = 539), and patients’ Ca and Vitamin D3 levels (n = 572), using a two-way ANOVA with FDR corrected p-value cut-off = 0.05. (B) A Venn diagram further excludes the common anti-diabetic (AD) (n = 57), proton pump inhibitor (PPI) (n = 3), and antihypertensive (AH) (n = 28) medication-related lipids, using a moderate t-test and considering fold change (FC 1.5) and cut-off p-value < 0.05. (C) A Venn diagram further excludes other drugs, anti-osteoporotic (AO) and statins, effects from the determined lipids (n = 333), using a moderate t-test and considering fold change (FC 1.5) and cut-off p-value < 0.050. Ultimately, 329 were identified as confounder- and medication-independent lipid molecules.