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. 2022 Oct 10;23(19):12017. doi: 10.3390/ijms231912017

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Lipidomic dysregulation associated with OP and ON. (A) Venn diagram shows the determination of the dysregulated lipids associated with OP compared with ON from the panel of confounder- and medications-independent lipids (n = 329); based on the fold change trend (cutoff ≥2, and <0.8), 36 lipid molecules were dysregulated in OP compared with ON (B) The expression of the dysregulated lipid molecules (n = 36) was demonstrated, where 18 were up-regulated and 18 were down-regulated in OP, compared with ON. (C) A bar graph shows the subclasses’ dysregulated lipid molecules (n = 36). (D,E) Bar-graphs showing the distribution of down- (n = 18) and up-regulated (n = 18) lipid molecules in subclasses.

Lipidomic dysregulation associated with OP and ON. (A) Venn diagram shows the determination of the dysregulated lipids associated with OP compared with ON from the panel of confounder- and medications-independent lipids (n = 329); based on the fold change trend (cutoff ≥2, and <0.8), 36 lipid molecules were dysregulated in OP compared with ON (B) The expression of the dysregulated lipid molecules (n = 36) was demonstrated, where 18 were up-regulated and 18 were down-regulated in OP, compared with ON. (C) A bar graph shows the subclasses’ dysregulated lipid molecules (n = 36). (D,E) Bar-graphs showing the distribution of down- (n = 18) and up-regulated (n = 18) lipid molecules in subclasses.