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. 2022 Oct 6;23(19):11888. doi: 10.3390/ijms231911888

Figure 1.

Figure 1

The fate of neurotrophin receptors/Sortilin interactions. The binding of proNT to the complex Sortilin/p75NTR triggers intracellular pathways that activate caspase 3, leading to cell death. On the other hand, the binding of matured NT to Trk receptors is responsible for NF-kB activation, which induces cell survival. The abbreviations used are: Trk, Tropomyosin Receptor Kinase; NT, neurotrophin; proNT, neurotrophin precursor; p75NTR, p75 neurotrophin receptor; NF-kB, nuclear factor kappa-light chain enhancer of activated B cells.