Table 1.
Boltzmann fitting parameters for the GJs of Cx46 and its variants.
| GJs | Vj Polarity | Gmin | V0 (mV) | A |
|---|---|---|---|---|
| Cx46 | + | 0.24 ± 0.07 1 | 39.1 ± 5.5 | 0.09 ± 0.04 |
| (n = 5) | − | 0.23 ± 0.09 | 38.6 ± 6.8 | 0.11 ± 0.09 |
| L10I | + | 0.22 ± 0.30 | 56.1 ± 17.8 | 0.06 ± 0.06 |
| (n = 4) | − | N/A | N/A | N/A |
| N13E | + | 0.17 ± 0.04 | 33.6 ± 3.6 | 0.16 ± 0.06 |
| (n = 4) | − | 0.17 ± 0.04 | 32.9 ± 1.8 | 0.15 ± 0.06 |
| A14V | + | 0.24 ± 0.04 | 35.1 ± 4.2 | 0.19 ± 0.14 |
| (n = 4) | − | 0.15 ± 0.04 | 37.1 ± 3.0 | 0.14 ± 0.08 |
| Q15N | + | 0.27 ± 0.12 | 37.3 ± 12.4 | 0.06 ± 0.04 |
| (n = 4) | − | 0.25 ± 0.08 | 32.3 ± 7.8 | 0.09 ± 0.06 |
1 Data are presented as mean ± SD and V0 are absolute values. Student’s t-test was used to compare the Boltzmann fitting parameters of each variant against those of wild-type at the same Vj polarity. No parameter showed statistically significant differences between each variant and wild-type GJs. N/A, not applicable.