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. 2022 Oct 3;27(19):6535. doi: 10.3390/molecules27196535

Figure 6.

Figure 6

Minimized average structure of SIRT1 in complex with p53-AMC peptide (green) and two molecules of compound 8 (purple). The ligand–protein and ligand–peptide H-bonds are highlighted as black dashed lines. For clarity, the side chains of R1, H2, and K3 of p53-AMC are not shown.