Table 5.
Association between the frequency of acid-suppressant prescription and study outcomes.
| Frequency of Prescriptions | ESRD | Overall Mortality | ||||
|---|---|---|---|---|---|---|
| Event | aHR * (95%CI) | p-Value | Event | aHR # (95%CI) | p-Value | |
| PPI | ||||||
| 0 (n = 4361) | 139 | 1 (reference) | 626 | 1 (reference) | ||
| 1 (n = 1922) | 125 | 1.22 (0.92–0.62) | 0.17 | 687 | 2.51 (2.22–2.83) | <0.0001 |
| 2 (n = 798) | 41 | 1.11 (0.78–1.60) | 0.56 | 197 | 1.61 (1.36–1.90) | <0.0001 |
| 3–4 (n = 838) | 36 | 0.92 (0.63–1.35) | 0.68 | 170 | 1.34 (1.13–1.60) | 0.001 |
| ≥5 (n = 808) | 68 | 1.46 (1.07–1.99) | 0.016 | 261 | 1.34 (1.15–1.56) | 0.0001 |
| H2RA | ||||||
| 0 (n = 4361) | 139 | 1 (reference) | 626 | 1 (reference) | ||
| 1 (n = 1595) | 38 | 0.52 (0.36–0.77) | 0.0011 | 258 | 1.25 (1.07–1.47) | 0.004 |
| 2 (n = 742) | 8 | 0.24 (0.12–0.50) | 0.0001 | 93 | 0.77 (0.62–0.96) | 0.02 |
| 3–4 (n = 771) | 18 | 0.47 (0.28–0.79) | 0.004 | 91 | 0.56 (0.45–0.70) | <0.0001 |
| ≥5 (n = 1253) | 17 | 0.28 (0.16–0.46) | <0.0001 | 189 | 0.44 (0.37–0.52) | <0.0001 |
Abbreviations: the same as Table 1, Table 2, Table 3 and Table 4. * Adjusted for all covariates (age per year, sex, comorbidities, number of medical visits, NSAID, and ACEI/ARB) and competing mortality. # Adjusted for all covariates (age per year, sex, comorbidities, number of medical visits, NSAID, and ACEI/ARB).