Table 2.
Cut-offs of lymphocyte count and NLR to discriminate between PD vs. HC and PD-NC vs. PD-MCI, with sensitivity, specificity, positive and negative likelihood ratios, and positive and negative predictive values.
| Lymphocyte Count Cut-off Values |
Sensitivity (95% CI) | Specificity (95% CI) | LR+ | LR− | PPV | NPV |
|---|---|---|---|---|---|---|
| PD vs. HC | ||||||
| ≤1.915 (103/microL) | 69% (56.20–79.38%) | 55.2% (42.45–67.25%) | 1.54 | 0.56 | 60.6% | 64% |
| PD-MCI vs. PD-NC | ||||||
| ≥1.790 (103/microL) | 65.2% (44.89–81.19%) | 82.1% (64.41–92.12%) | 3.64 | 0.42 | 75% | 74.2% |
| NLR Cut-off Values | Sensitivity (95% CI) | Specificity (95% CI) | LR+ | LR− | PPV | NPV |
| PD vs. HC | ||||||
| ≥2.065 | 69% (56.20–79.38%) | 48.3% (35.93–60.84%) | 1.33 | 0.64 | 57.1% | 60.9% |
| PD-MCI vs. PD-NC | ||||||
| ≤2.295 | 69.6% (49.13–84.4%) | 67.8% (49.34–82.07%) | 2.16 | 0.45 | 64% | 73.1% |
Abbreviations: NLR, neutrophil-to-lymphocyte ratio; LR+, positive likelihood ratio; LR−, negative likelihood ratio; PD-MCI, PD with cognitive impairment; PD-NC, PD with normal cognition; PPV, positive predictive value; NPV, negative predictive value.