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. 2022 Oct 4;27(19):6571. doi: 10.3390/molecules27196571

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The eukaryotic molybdenum cofactor biosynthesis. Molybdenum cofactor (Moco) biosynthesis comprises four subsequent reaction steps, each giving yield to the intermediates shown: The reaction product of the first reaction step is cyclic pyranopterin monophosphate (cPMP) which is subsequently converted to molybdopterin (MPT) in the second reaction step. MPT is adenylyated, yielding MPT-AMP that is then converted to Moco-AMP. In the ultimate, fourth reaction step, the phosphoanhydride-bond within Moco-AMP is hydrolyzed and Moco is released.