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. 2022 Sep 24;11(19):5632. doi: 10.3390/jcm11195632

Table A2.

The SEQDESIGN Procedure.

Design: One-Sided O’Brien–Fleming
Design Information
Statistic Distribution Normal
Boundary Scale Standardized Z
Alternative Hypothesis Lower
Early Stop Accept/Reject Null
Method O’Brien-Fleming
Boundary Key Both
Alternative Reference −0.08
Number of Stages 2
Alpha 0.025
Beta 0.2
Power 0.8
Max Information (Percent of Fixed Sample) 105.8601
Max Information 1298.255
Null Ref ASN (Percent of Fixed Sample) 65.61561
Alt Ref ASN (Percent of Fixed Sample) 88.24682
Adj Design Alpha 0.025
Adj Design Beta 0.19907
Adj Design Power 0.80093
Adj Design Max Information (Percent of Fixed Sample) 105.8615
Adj Design Max Information 1301.37
Adj Design Null Ref ASN (Percent of Fixed Sample) 65.70521
Adj Design Alt Ref ASN (Percent of Fixed Sample) 88.12149