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. 2022 Oct 15;20:450. doi: 10.1186/s12951-022-01648-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — InSyTe FLECT/CT imaging of mice with left carotid ferric chloride–induced thrombosis using a targeted NIR fluorescent fluorophore. A NIR fluorescence signal of Targ-Cy7 in collected blood samples as determined by IVIS^® Lumina to determine in vivo circulatory half-life before imaging using FLECT-CT. B FLECT-CT scans of mice with left carotid thrombosis showing selective binding of targeting fluoroprobe (Targ-Cy7; bottom panel), compared to mutated control (Mut-Cy7; top panel). C NIR fluorescence units of Targ-Cy7 and Mut-Cy7. D Representative images of ferric chloride–injured carotid artery (left) and contralateral non-injured carotid artery (right), where nuclear stain (DAPI) is blue and platelet-specific (CD41-allophycocyanin) is red. E Further analysis of detected signal in each mouse shows a strongly significant correlation to the weight of its ex vivo thrombus. Adapted with permission from [57].

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