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. 2022 Oct 16;23:49. doi: 10.1186/s12865-022-00524-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Low-dose IL-2 can improve salivary secretion in a Sjögren’s syndrome model. a Experimental schema of IL-2 treatment: Mice were injected subcutaneously with IL-2, once daily for the first 6 days, and every 4 days for the subsequent maintenance treatment. The mice in the short-course and long- course group group were sacrificed at the age of 9 weeks and 23 weeks respectively (n = 5). b and c Changes in body weight parameters of b short-course group and c long-course group(n = 5). d Changes in salivary flow rate per unit body weight of mice treated with IL-2 (μl/g) (n = 5)