Table 1.
Cohort characteristics
| Variable | SABRE baseline | SABRE follow-up | Born in Bradford | Cross-cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| European mean (SD) or n (%) | South Asian mean (SD) or n (%), | p valuea | European mean (SD) or n (%) | South Asian mean (SD) or n (%), | p valuea | White British mean (SD) or n (%) | Asian Pakistani mean (SD) or n (%), | p valuea | SABRE baseline | BiB | p valueb | |
| N (%) | 400 (50.0) | 400 (50.0) | 66 (47.5) | 73 (52.5) | 444 (48.5) | 472 (51.5) | 800 (46.6) | 916 (53.4) | ||||
| Males (%) | 400 (100) | 400 (100) | 66 (100) | 73 (100) | 0 (0) | 0 (0) | 800 (100) | 0 (0) | ||||
| Age (years) | 52.3 (7.1) | 51.0 (7.1) | 0.084 | 68.6 (5.3) | 69.0 (5.8) | 0.634 | 26.8 (6.1) | 28 (5.3) | 0.00205 | 51.9 (7.2) | 27 (5.7) | 0 |
| BMI (kg/m2) | 26.1 (3.7) | 26.0 (3.6) | 0.441 | 26.7 (3.1) | 26 (4.0) | 0.318 | 27.1 (6.3) | 26 (5.2) | 0.00269 | 26 (3.6) | 26 (5.8) | 0.0542 |
| Bcell (%) | 7.6 (2.09) | 9.1 (2.69) | 9.58E−20 | 8.3 (2.78) | 10.0(6.84) | 0.0424 | 4.75 (1.2) | 5.7 (1.5) | 1.62E−27 | 8.35 (2.5) | 5.3 (1.4) | 2.03E−151 |
| CD4T (%) | 14.5 (4.84) | 14.0 (4.32) | 0.00549 | 16.9 (5.74) | 15.0 (6.38) | 0.102 | 11.8 (2.6) | 12 (3.0) | 0.00104 | 14 (4.6) | 12 (2.8) | 1.50E−23 |
| CD8T (%) | 1.2 (2.23) | 2.1 (3.04) | 1.53E−06 | 0.5 (1.5) | 1.6 (2.74) | 0.00651 | 0.126 (0.7) | 0.36 (1.1) | 0.000122 | 1.66 (2.7) | 0.25 (0.9) | 1.24E−40 |
| Eos (%) | 0.06(0.368) | 0.26 (1.15) | 0.000598 | 0.2 (0.722) | 0.7 (1.78) | 0.0209 | 0.0185 (0.2) | 0.19 (0.8) | 1.57E−05 | 0.159 (0.9) | 0.11 (0.6) | 0.154 |
| Mono (%) | 10.3 (1.94) | 9.9 (1.69) | 0.00166 | 10.7 (2.04) | 9.5 (1.67) | 0.000175 | 11.2 (1.6) | 12 (2.01) | 0.00113 | 10.1 (1.8) | 11 (1.8) | 8.13E−45 |
| Neu (%) | 56.2 (8.52) | 53 (8.47) | 3.35E−06 | 53.9 (10.6) | 52 (13.2) | 0.308 | 68.7 (5.0) | 65 (6.97) | 1.77E−20 | 54.8 (8.6) | 67 (6.4) | 1.74E−171 |
| NK (%) | 15.8 (4.41) | 18 (4.65) | 8.97E−09 | 16 (4.7) | 18 (4.8) | 0.0227 | 6.55 (2.4) | 8.4 (2.74) | 8.51E−26 | 16.7 (4.6) | 7.5 (2.7) | 1.78E−295 |
| Ever smoking (%) | 291 (72.8) | 127 (31.8) | 1.60E−30 | 45 (68.2) | 22 (31.1) | 1.60E−05 | 260 (58.6) | 35 (7.4) | 6.40E−61 | 418 (52.3) | 295 (32.2) | 1.80E−17 |
at test or χ2 for ethnic differences
bt test or χ2 comparing SABRE baseline and Born in Bradford