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. 2022 Oct 15;20:471. doi: 10.1186/s12967-022-03688-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Inflamed TME in high Rad-TILs revealed by transcriptomics analysis. A Comparison of immune cell subpopulation between high and low Rad-TILs. The p values were calculated using Wilcoxon test. Specific p values were denoted on each cell type. B, C Expression of immune-related signatures in high and low Rad-TILs. Cytolytic activity (B) and T cell inflamed gene expression profiles (GEPs) (C) of two groups. The p values were calculated using Wilcoxon test. D, J Distinct expression of immune-related molecules on cell surface, including costimulators (D), coinhibitors (E) and major histocompatibility complex (J) between two groups. Distinct immune-related secretary molecules, including interleukins (F), chemokines (G), interferons (H) and colony-stimulating factors (I) between two groups. The p values calculated by Wilcoxon test were adjusted to false discovery rate (FDR) using the Benjamini–Hochberg procedure in multiple comparisons. Specific FDR values were denoted on each molecule