Mon inhibits the activation of NF-κB pathway in LPS-induced inflammatory mice and osteoclast derived from BMMs (n = 3). (A(a)) Representative imagines of Western blot for the expression of TRAF6, P-P65, P65, and IKBα in bone tissue of LPS-stimulated model mice; (A(b–d)) quantitative analysis of TRAF6, P-P65, P65, and IKBα, respectively. # p < 0.05, ## p < 0.01 compared with Sham group; * p < 0.05, ** p< 0.01 compared with LPS group. (B(a)) Representative imagines of Western blot for the expression of TRAF6, P-P65, P65, and IKBα in osteoclast; (B(b–d)) quantitative analysis of TRAF6, P-P65, P65, and IKBα in osteoclast, respectively, * p < 0.05, ** p < 0.01 compared with LPS group at corresponding time point. (B(e)) The translocation of P65 of osteoclast stimulated by LPS. The data are expressed as means ± SD.