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Two different models of SL perception showing the conformational change in D14. The figures are modified from Mashiguchi et al. [30]. (a) The hydrolysis intermediate derived from the D-ring part of SLs covalently linked with the receptor, D14, and resulted in a conformational change [52]. (b) The intact SL molecules cause a conformational change in D14, and D14 then returns to its catalytically active form [57].
