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. 2022 Sep 24;14(19):3966. doi: 10.3390/nu14193966

Figure 5.

Figure 5

Melatonin (MT) inhibited the degradation of the interleukin 1-beta (IL-1β)-induced chondrocyte extracellular matrix. (A,C) Western blot (WB) detected the expression levels of matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-13 (MMP-13), ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS-4), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and collagen II. (B,D) Real-time PCR (qRT-PCR) detected the transcript levels of MMP-3, MMP-13, ADAMTS-4, COX-2, and collagen II. * p < 0.05, ** p < 0.01 (compared to the model group).