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. 2022 Sep 27;11(19):5722. doi: 10.3390/jcm11195722

Table 2.

Studies comparing c-IVF and ICSI outcomes in women with DOR in the absence of male factor infertility.

Author, Year Design Analysis Years Number of Oocytes Number of Patients/Cycles Result
Moreno et al., 1998 Prospective 1996–1997 ≤6, ≤3 IVF = 52 ICSI = 52

  • PR/IR/FR/FF/embryo quality = comparable
Luna et al., 2011 Retrospective 2002–2009 ≤4 IVF = 179 ICSI = 171

  • CPR/FR/IR/FF/CR/MR = comparable
Tannus et al., 2017 Retrospective 2012–2015 ≤3 IVF = 72 ICSI = 164

  • LBR/CPR/FF/FR = comparable
Liu et al., 2018 Retrospective 2011–2016 ≤5 IVF = 534 ICSI = 110

  • CPR/LBR/MR/CR = comparable

  • IR = IVF 15.11% vs. ICSI 7.75%

  • CLBR = IVF 14.59% vs. ICSI 5.56%

  • FR = IVF 61.56% vs. ICSI 76.00%

Guo et al., 2018 Retrospective 2012–2015 1, 2, 3 or 4 IVF = 870 ICSI = 435

  • CPR/CLBR = comparable
Drakopoulos et al., 2019 Retrospective Multicentre 2009–2014 1–3 IVF = 90 ICSI = 600

  • FR/LBR/CLBR = comparable
Supramaniam et al., 2020 Retrospective 1998–2016 ≤3 IVF= 33,436 ICSI = 29,205

  • LBR/CPR/FF = comparable

  • FR = 2% lower for IVF

Liu et al., 2020 Retrospective 2012–2016 ≤6 IVF = 5071 ICSI = 734

  • LBR/all perinatal outcomes = comparable
Haas et al., 2020 Prospective 2018–2019 mean 4.3 IVF= 258 ICSI= 257

  • FR/number of cleavage-stage and top-quality embryo = comparable
Isikoglu et al., 2022 Retrospective 2017–2019 ≤3 IVF = 77ICSI =65

  • IR/LBR/FF/CR = comparable

  • FR = IVF 85.68% vs. ICSI 72.58%

Bold font in the results column denotes significant findings. CPR: clinical pregnancy rate; FR: fertilization rate; IR: implantation rate; FF: fertilization failure, CR: cancellation rate; MR: miscarriage rate; LBR: live birth rate; CLBR: cumulative live birth rate; PR: pregnancy rate.