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In vitro combination effect of compounds 1, 2, and 3 with isoniazid (INH) and rifampicin (RIF) against Mtb (H37Ra). Anti-mycobacterial activity against Mtb (H37Ra) of compounds 1, 2, and 3 was determined at concentrations of 25, 12.5, 6.25, and 3.12 µg/mL in combination with isoniazid (0.05 µg/mL) and rifampicin (0.012 ng/mL). The experiments were performed on three separate days, in triplicate on each day and the mean percent inhibition was calculated.
